EXPERIMENTS WITH AN INSTRUMENTED TWIN-SCREW EXTRUDER USING A SINGLE-STEP GRANULATION EXTRUSION PROCESS

Citation
P. Kleinebudde et H. Lindner, EXPERIMENTS WITH AN INSTRUMENTED TWIN-SCREW EXTRUDER USING A SINGLE-STEP GRANULATION EXTRUSION PROCESS, International journal of pharmaceutics, 94(1-3), 1993, pp. 49-58
Citations number
27
Categorie Soggetti
Pharmacology & Pharmacy
ISSN journal
03785173
Volume
94
Issue
1-3
Year of publication
1993
Pages
49 - 58
Database
ISI
SICI code
0378-5173(1993)94:1-3<49:EWAITE>2.0.ZU;2-0
Abstract
Preliminary studies with an instrumented, co-rotating twin-screw extru der were performed. The variation of water content of the extruded mas s is dependent on the accuracy of both dry powder and granulation liqu id feed rate. Using a given powder feed rate it is easy to vary the wa ter content by changing the liquid feed rate. Operating the twin-screw extruder in this way the extruder barrel is not completely filled wit h wet mass. The steady state mass is dependent on both screw speed and mass flow rate. This leads to different behaviour of extrusion proces s variables compared to extruders with completely filled barrels. With a central composite design the influence of screw speed and water con tent on passage time, steady state mass and the process variables corr ected power consumption, pressure and end temperature of extrudate wer e studied. Water content is the most important variable for the extrus ion process variables. For further studies it is strictly recommended either to control the water content or to use it as a variable.