P. Kleinebudde et H. Lindner, EXPERIMENTS WITH AN INSTRUMENTED TWIN-SCREW EXTRUDER USING A SINGLE-STEP GRANULATION EXTRUSION PROCESS, International journal of pharmaceutics, 94(1-3), 1993, pp. 49-58
Preliminary studies with an instrumented, co-rotating twin-screw extru
der were performed. The variation of water content of the extruded mas
s is dependent on the accuracy of both dry powder and granulation liqu
id feed rate. Using a given powder feed rate it is easy to vary the wa
ter content by changing the liquid feed rate. Operating the twin-screw
extruder in this way the extruder barrel is not completely filled wit
h wet mass. The steady state mass is dependent on both screw speed and
mass flow rate. This leads to different behaviour of extrusion proces
s variables compared to extruders with completely filled barrels. With
a central composite design the influence of screw speed and water con
tent on passage time, steady state mass and the process variables corr
ected power consumption, pressure and end temperature of extrudate wer
e studied. Water content is the most important variable for the extrus
ion process variables. For further studies it is strictly recommended
either to control the water content or to use it as a variable.