INHIBITION OF GABA(A) RECEPTOR-MEDIATED CURRENT RESPONSES BY ENOXACIN(NEW QUINOLONE) AND FELBINAC (NONSTEROIDAL ANTIINFLAMMATORY DRUG) IN XENOPUS-OOCYTES INJECTED WITH MOUSE-BRAIN MESSENGER-RNA

Authors
KAWAKAMI J SHIMOKAWA M YAMAMOTO K SAWADA Y ASANUMA A YANAGISAWA K IGA T
Citation
J. Kawakami et al., INHIBITION OF GABA(A) RECEPTOR-MEDIATED CURRENT RESPONSES BY ENOXACIN(NEW QUINOLONE) AND FELBINAC (NONSTEROIDAL ANTIINFLAMMATORY DRUG) IN XENOPUS-OOCYTES INJECTED WITH MOUSE-BRAIN MESSENGER-RNA, Biological & pharmaceutical bulletin, 16(7), 1993, pp. 726-728
Citations number
22
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Biological & pharmaceutical bulletin → ACNP
ISSN journal
09186158
Volume
16
Issue
7
Year of publication
1993
Pages
726 - 728
Database
ISI
SICI code
0918-6158(1993)16:7<726:IOGRCR>2.0.ZU;2-H
Abstract
The convulsant interaction between enoxacin (ENX), a new quinolone ant ibacterial agent (NQ), and felbinac (FLB), a non-steroidal anti-inflam matory drug (NSAID), in vivo was reproduced as the change of GABA-indu ced current response in Xenopus oocytes injected with mouse brain mRNA . GABA (10 muM) response was inhibited by ENX in a dose-dependent mann er, and IC50 of ENX was 96 muM. Moreover, the inhibitory effect of ENX was 80-fold potentiated in the presence of 10 muM FLB. The GABA(A)-an tagonistic interaction between these two drugs in vitro was considered a possible mechanism of convulsant reaction after concomitant adminis tration of NQs and NSAIDs in vivo.