ALKALINE-PHOSPHATASE AND PHOSPHOTYROSINE PHOSPHATASE-ACTIVITIES OF CULTURED AMNIOTIC CELLS WITH TRISOMY-18

Authors
VERGNES H GROZDEA J BRISSONLOUGARRE A BOURROUILLOU G COLOMBIES P
Citation
H. Vergnes et al., ALKALINE-PHOSPHATASE AND PHOSPHOTYROSINE PHOSPHATASE-ACTIVITIES OF CULTURED AMNIOTIC CELLS WITH TRISOMY-18, Enzyme, 46(6), 1992, pp. 284-286
Citations number
13
Categorie Soggetti
Biology
Journal title
Enzyme → ACNP
ISSN journal
00139432
Volume
46
Issue
6
Year of publication
1992
Pages
284 - 286
Database
ISI
SICI code
0013-9432(1992)46:6<284:AAPPOC>2.0.ZU;2-C
Abstract
In cultured amniotic cells from fetuses with Edward's syndrome (trisom y 18), the activities of two protein phosphatases, alkaline phosphatas e and phosphotyrosine phosphatase, were measured. Comparison with norm al fetal cells showed a different behavior for each enzyme. Alkaline p hosphatase was significantly lowered while phosphotyrosine phosphatase remained at normal levels. The interest of these enzyme assays in the screening procedure of this severe chromosome defect is discussed.