In 24 patients with presumed osteoid osteoma in the appendicular skele
ton (n = 23) and lumbar spine (n = 1), percutaneous resection with a d
rill system and computed tomographic (CT) guidance was performed. In t
he procedure, a 7-mm-diameter toothed drill inserted over a guide wire
is used to remove the nidus. Twenty-three patients were successfully
treated. Histologic confirmation of osteoid osteoma was obtained in 19
cases. In one patient, open surgery with bone grafting and osteosynth
esis was necessary because of inadvertent extensive bone resection res
ulting from damage to the drill. All patients have remained free of pa
in and recurrence for 3-24 months. Although the procedure was effectiv
e in all patients, the 7-mm diameter of the toothed drill may cause di
fficulty in small bones or even danger in areas such as the posterior
vertebral arch. In locations such as the tubular bones of the lower ex
tremity and the femoral neck, however, this technique is feasible and
may become the treatment of choice for osteoid osteoma.