A MATCHED STUDY OF SURGICALLY TREATED STAGE-IB ADENOSQUAMOUS CARCINOMA AND ADENOCARCINOMA OF THE UTERINE CERVIX

Thirty-eight patients with surgically treated stage IB adenosquamous c arcinoma of the uterine cervix (AS) have been matched with patients wi th other histologic subtypes of adenocarcinoma (A) for stage, lesion s ize, node status, grade of adenocarcinoma and age at diagnosis. An add itional six patients with AS were unable to be matched. Overall 5-year survival and disease-free survival for the matched AS and A were not significantly different, 83 vs. 90%, and 78 vs. 81% nor were the numbe r of recurrences, 8/38 AS vs. 6/38 A, but the mean time to recurrence was significantly shorter in the AS group: 11 vs. 32 months (P = 0.003 ). A subgroup of AS with a high risk of a poor outcome can be identifi ed based on either lesion size greater-than-or-equal-to 4 cm, depth of invasion greater-than-or-equal-to 10 mm or plevic lymph node metastas is. These patients may be suitable candidates for adjuvant therapy bef ore or after surgical treatment.