ORAL MUCOSAL ADHESIVE OINTMENT CONTAINING LIPOSOMAL CORTICOSTEROID

A co-polymer of methacrylic acid and methacrylic acid methyl ester (Eu dispert) was used to formulate a mucoadhesive ointment. Liposomes cont aining triamcinolone acetonide were incorporated into (a) the Eudisper t ointment, which contains 11% (w/w) of the neutralized polymer and 0. 5% (w/w) gelatin, and (b) Orabase. The in vitro drug release and disso lution behaviour of these formulations were investigated. A clinical t rial is currently being carried out and the initial findings indicate that the liposomal formulations are well tolerated and no local irrita tion has been observed.