FORCE-TIME CURVES OF A MODERN ROTARY TABLET MACHINE .2. INFLUENCE OF COMPRESSION FORCE AND TABLETTING SPEED ON THE DEFORMATION MECHANISMS OF PHARMACEUTICAL SUBSTANCES

Authors
VOGEL PJ SCHMIDT PC
Citation
Pj. Vogel et Pc. Schmidt, FORCE-TIME CURVES OF A MODERN ROTARY TABLET MACHINE .2. INFLUENCE OF COMPRESSION FORCE AND TABLETTING SPEED ON THE DEFORMATION MECHANISMS OF PHARMACEUTICAL SUBSTANCES, Drug development and industrial pharmacy, 19(15), 1993, pp. 1917-1930
Citations number
6
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Drug development and industrial pharmacy → ACNP
ISSN journal
03639045
Volume
19
Issue
15
Year of publication
1993
Pages
1917 - 1930
Database
ISI
SICI code
0363-9045(1993)19:15<1917:FCOAMR>2.0.ZU;2-O
Abstract
Investigations on the compaction mechanisms of pharmaceutical substanc es using an evaluation method for force-time curves of a rotary tablet machine are presented. The machine speed is shown to have only little influence on the compaction behavior. Looking at the compression forc e, not only a quantification of plastic or brittle deformation behavio r as well as a detection of elastic relaxation is presented but also a description of the disposition to porosity reduction.