The use of the immune system for the treatment of cancer is still deba
ted. Recent advances in antigen presentation and recognition mechanism
s, and the characterization of tumor-specific antigens generating a T
cell response are crucial steps for the stimulation of research in thi
s direction. These advances should allow the development of selective
immunotherapy, either passive (infusion of lymphocytes with specific r
ecognition of autologous tumor) or active (vaccination), and the evalu
ation of this new approach in cancer treatment strategies.