INVESTIGATION OF THE METABOLISM OF FELODIPINE USING ONLINE LIQUID-CHROMATOGRAPHY UV DIODE-ARRAY DETECTION ATMOSPHERIC-PRESSURE CHEMICAL-IONIZATION MASS-SPECTROMETRY AS A DIAGNOSTIC-TOOL

Authors
MACRAE PV JONES BC TODD JFJ
Citation
Pv. Macrae et al., INVESTIGATION OF THE METABOLISM OF FELODIPINE USING ONLINE LIQUID-CHROMATOGRAPHY UV DIODE-ARRAY DETECTION ATMOSPHERIC-PRESSURE CHEMICAL-IONIZATION MASS-SPECTROMETRY AS A DIAGNOSTIC-TOOL, Rapid communications in mass spectrometry, 7(7), 1993, pp. 605-609
Citations number
7
Categorie Soggetti
Spectroscopy,"Chemistry Analytical
Journal title
Rapid communications in mass spectrometry → ACNP
ISSN journal
09514198
Volume
7
Issue
7
Year of publication
1993
Pages
605 - 609
Database
ISI
SICI code
0951-4198(1993)7:7<605:IOTMOF>2.0.ZU;2-E
Abstract
The utility of on-line liquid chromatography coupled to UV diode array detection and atmospheric pressure chemical ionization mass spectrome try for the analysis of microsomal metabolites of felodipine has been investigated. A previously unreported metabolite of felodipine, extrac ted from male rat microsomes, has been detected using this technique. UV diode array detection has been used to characterize this metabolite as a dihydropyridine metabolite and tandem mass spectrometry data use d to assign a structure.