THE SERUM COMPLEMENT-SYSTEM IN CHILDREN ON CONTINUOUS AMBULATORY PERITONEAL-DIALYSIS

Citation
Re. Reddingius et al., THE SERUM COMPLEMENT-SYSTEM IN CHILDREN ON CONTINUOUS AMBULATORY PERITONEAL-DIALYSIS, Peritoneal dialysis international, 13(3), 1993, pp. 214-218
Citations number
36
Categorie Soggetti
Urology & Nephrology
ISSN journal
08968608
Volume
13
Issue
3
Year of publication
1993
Pages
214 - 218
Database
ISI
SICI code
0896-8608(1993)13:3<214:TSCICO>2.0.ZU;2-J
Abstract
Objective: During continuous ambulatory peritoneal dialysis (CAPD), th e loss of complement factors via the dialysate may cause complement de ficiencies. This hypothesis was tested in a group of children treated with CAPD. Design: Classical (CH50) and alternative (AP50) complement activity and serum levels of factors C1q, C3, C4, C3d, B, D, and P in CAPD patients were compared to normal controls and to children with pr eterminal renal failure. Setting: Patients were seen in a university h ospital; normal controls were seen in an outpatient clinic of a genera l hospital. Patients: A group of 22 children on CAPD was compared to a normal control group of 44 children and to a group of 12 children wit h preterminal renal failure with a creatinine clearance below 25 mL/mi n/1.73 m2. Results: CH50, AP50, C3, and B were not significantly diffe rent from the control group in both the CAPD and preterminal groups. F actors C1q (p=0.01) and C4, C3d, D, and P (p<0.001) were higher in the CAPD group in comparison to the normal control group. The factors D ( p<0.001) and P (p=0.02) were also elevated in the preterminal group. F or the measured factors there was no significant difference between th e CAPD group and the preterminal group. Conclusions: There is no defic iency of complement in children treated with CAPD. High levels of C3d and D can be explained by the reduction of their elimination by the ki dney. The increased levels of the other factors are presumably due to increased synthesis in renal failure. This does not seem to be caused by CAPD.