AMYGDALA KINDLING RATE IS ALTERED IN RATS WITH A DEFICIT IN THE RESPONSIVENESS OF THE HYPOTHALAMO-PITUITARY-ADRENAL AXIS

Authors
WEISS GK CASTILLO N FERNANDEZ M
Citation
Gk. Weiss et al., AMYGDALA KINDLING RATE IS ALTERED IN RATS WITH A DEFICIT IN THE RESPONSIVENESS OF THE HYPOTHALAMO-PITUITARY-ADRENAL AXIS, Neuroscience letters, 157(1), 1993, pp. 91-94
Citations number
33
Categorie Soggetti
Neurosciences
Journal title
Neuroscience letters → ACNP
ISSN journal
03043940
Volume
157
Issue
1
Year of publication
1993
Pages
91 - 94
Database
ISI
SICI code
0304-3940(1993)157:1<91:AKRIAI>2.0.ZU;2-M
Abstract
Fisher and Lewis rats were amygdala kindled in the morning and in the evening. Fisher rats displayed a diurnal variation in the rate of kind ling through stage 2 which did not exist in the Lewis rats. Lewis rats also take much longer to kindle through stage 2 and a subcutaneous co rticosterone pellet accelerates this rate. These observations are cons istent with the hypothesis that the hormones of the hypothalamo-pituit ary-adrenal (HPA) axis. particularly the glucorcorticoids, play a role in epileptogenesis.