ENZYMES IN THICK FILAMENTS OF VERTEBRATE STRIATED MUSCLES

This review presents an update on three enzymes of thick filaments of vertebrate striated muscles: creatine kinase (CK), AMP-deaminase, and phosphofructokinase (PFK). Physicochemical, enzymatic, and regulatory properties of the enzymes are described, and their localization in va rious zones of thick filaments are defined. Functional significance of localization of these enzymes is discussed in the framework of advanc ed concepts concerning the role of enzyme adsorption on subcellular st ructures in the regulation of metabolism.