MACROCYCLIC AMIDOPHOSPHORYL POLYETHERS - BIOLOGICAL-ACTIVITY, MOLECULAR-STRUCTURE, AND STRUCTURE OF THE COMPLEX WITH CALCIUM THIOCYANATE

The antihypoxic and anticonvulsant activity of eight new amidophosphor yl derivatives of crown ethers was investigated. It was found that som e of them exhibit pronounced antihypoxic activity. The results of an x -ray structural and IR spectroscopic study of dibenzo-N-phenylphosphon yl-14-crown-5 (a = 9.818, b = 16.062, c = 15.925 angstrom; gamma = 124 .90-degrees; V = 2072 angstrom3; M = 417.2; d = 1.33 g/cm3 for Z = 4, 1955 independent reflections [I > 3sigma(I)] in a DAR-UM in CuK(alpha) radiation P2(1)/b space group, R = 5.2%) and dibenzo-N-adamantylphosp honyl-14-crown-5 compounds (a = 11.077, b = 15.936, c = 16.771 angstro m; gamma = 56.05-degrees; V = 2456 angstrom3; M = 486.3; d = 1.31 g/cm 3 for Z = 4, 2164 independent reflections [I > 3sigma(I)] in a DAR-UM in CuK(alpha) radiation, P2(1)/b-space group, R = 5.1%) are reported. Some details of the structure of the dibenzo-N-phenylphosphonyl-14-cro wn-5-complex with calcium thiocyanate and water are discussed; a polyh edron with a coordination number of six was found for the first time f or calcium complexes with macrocyclic ligands. The combined examinatio n of the results of the biological, x-ray structural, and IR spectrosc opic study of macrocyclic, 14-member ligands suggested that the nature of the substituents at phosphorus affect the conformational state of the macrocycle, which remains unchanged in complexation in the investi gated conditions.