A. Represa et al., MOSSY FIBER SPROUTING IN EPILEPTIC RATS IS ASSOCIATED WITH A TRANSIENT INCREASED EXPRESSION OF ALPHA-TUBULIN, Neuroscience letters, 156(1-2), 1993, pp. 149-152
Kainate-induced seizures lead to marked increases of alpha-tubulin mRN
A and protein immunoreactivity in the rat dentate gyrus. The increase
in alpha-tubulin mRNA was restricted to the granule cell bodies. Alpha
-tubulin immunoreactivity was enhanced in granule cell dendrites and a
xons (the mossy fibers), in the molecular layer. These changes peaked
6-12 days after kainate treatment and preceded the collateral sproutin
g of mossy fibers which occur 12 to 30 days after seizures. The presen
t results suggest that microtubule formation contributes to the synapt
ic rearrangements which take place in the hippocampus after seizures.