INTRACAVERNOUS APPLICATION OF SIN-I IN RABBIT AND MAN - FUNCTIONAL AND TOXICOLOGICAL RESULTS

The mode of action of the active metabolite SIN-I of the vasodilator p rodrug molsidomine was studied in vitro and in vivo in corpus cavernos um of rabbit and man. SIN-I produces a dose-dependent relaxation of is olated human cavernous smooth muscle strips. In the rabbit, the intrac avernous application of SIN-I increased the intracavernous pressure to a full erection (approximately 100 cm H2O). This response wa shighly reproductible. SIN-I was also injected intracavernously 6 times in fiv e rabbits over 2 weeks; no inflammatory or fibrotic reactions were fou nd on histology. SIN-I may be a reliable drug for the treatment of imp otence without side-effects.