We consider a lattice model of three-dimensional vesicles in which the
boundary of the vesicle is a self-avoiding plaquette surface, homeomo
rphic to a sphere. Surfaces with fixed area can enclose a variety of d
ifferent volumes and we associate a fugacity with the enclosed volume
to mimic the effect of a pressure difference across the surface. Pairs
of plaquettes which share a common edge can be in the same plane or n
ormal to each other and we associate a fugacity with adjacent pairs of
plaquettes at right angles to represent a surface stiffness term. We
discuss the behaviour of the surfaces in the infinite surface area lim
it, as a function of these two fugacities.