FUNCTIONAL MODELS FOR IRON-BLEOMYCIN

Authors
ROELFES G LUBBEN M LEPPARD SW SCHUDDE EP HERMANT RM HAGE R WILKINSON EC QUE L FERINGA BL
Citation
G. Roelfes et al., FUNCTIONAL MODELS FOR IRON-BLEOMYCIN, Journal of molecular catalysis. A, Chemical, 117(1-3), 1997, pp. 223-227
Citations number
20
Categorie Soggetti
Chemistry Physical
Journal title
Journal of molecular catalysis. A, Chemical → ACNP
ISSN journal
13811169
Volume
117
Issue
1-3
Year of publication
1997
Pages
223 - 227
Database
ISI
SICI code
1381-1169(1997)117:1-3<223:FMFI>2.0.ZU;2-2
Abstract
A new pentadentate ligand, N, N-bis(2-pyridylmethyl)-N-bis(2-pyridyl)m ethylamine (N4Py), has been prepared. The corresponding iron(II) compl ex, [N4PyFe(CH3CN)](ClO4)(2), serves as a functional model for the act ive site of iron-bleomycin. Upon treatment with H2O2 the formation of a purple intermediate has been observed, which has been characterized as an iron(III)-hydroperoxide complex. This N4Py-iron-hydroperoxide sy stem has proven to be an active oxidation catalyst.