A NEW IMMUNOSTIMULATORY COMPLEX (PICKCA) IN EXPERIMENTAL RABIES - ANTIVIRAL AND ADJUVANT EFFECTS

Authors
LIN HX GONTIER C SARON MF PERRIN P
Citation
Hx. Lin et al., A NEW IMMUNOSTIMULATORY COMPLEX (PICKCA) IN EXPERIMENTAL RABIES - ANTIVIRAL AND ADJUVANT EFFECTS, Archives of virology, 131(3-4), 1993, pp. 307-319
Citations number
32
Categorie Soggetti
Virology
Journal title
Archives of virology → ACNP
ISSN journal
03048608
Volume
131
Issue
3-4
Year of publication
1993
Pages
307 - 319
Database
ISI
SICI code
0304-8608(1993)131:3-4<307:ANIC(I>2.0.ZU;2-G
Abstract
The activity of an immunostimulatory complex (PICKCa) which is widely used against several human diseases in China was tested in experimenta l rabies prophylaxis. PICKCa protected mice against peripheral infecti on with both fixed and wild rabies strains. It also enhanced the prote ctive activity of an experimental rabies vaccine injected either befor e or after rabies infection. PICKCa enhanced both non-specific immune responses and specific immunity including antibody production and cell mediated immunity as assessed by interleukin-2 production.