DEOXYCORTICOSTERONE, 11-BETA-HYDROXYLASE AND THE ADRENAL-CORTEX

Authors
SPOUDEAS HA SLATER JDH RUMSBY G HONOUR JW BROOK CGD
Citation
Ha. Spoudeas et al., DEOXYCORTICOSTERONE, 11-BETA-HYDROXYLASE AND THE ADRENAL-CORTEX, Clinical endocrinology, 39(2), 1993, pp. 245-251
Citations number
35
Categorie Soggetti
Endocrynology & Metabolism
Journal title
Clinical endocrinology → ACNP
ISSN journal
03000664
Volume
39
Issue
2
Year of publication
1993
Pages
245 - 251
Database
ISI
SICI code
0300-0664(1993)39:2<245:D1ATA>2.0.ZU;2-C
Abstract
We report a child in whom DOC excess secondary to congenital adrenal h yperplasia (CAH, 11beta-hydroxylase deficiency) caused malignant hyper tension. Clinical and metabolic control could be achieved only by repl acement of both glucocorticoid and mineralocorticoid, thus confirming in clinical practice the hypothesis that DOC is produced from both the zonae fasciculata and glomerulosa of the adrenal cortex under the ind ependent control of the ACTH and renin-angiotensin systems respectivel y.