T-CELL-DEPENDENT IMMUNOBIOLOGICAL ACTIVITY OF A DESMURAMYL ANALOG OF MURAMYL DIPEPTIDE, ADAMANTYLAMIDE DIPEPTIDE (ADDP), AND D-ISOGLUTAMINE

The present experiments demonstrate that, similar to immunomodulatory muramyl dipeptide, its desmuramyl analog adamantylamide dipeptide is a ble to induce mild and fully reversible paw edema in mice. This effect is an immune-related phenomenon depending on the activation of T-cell /macrophage interactions and on production of prostaglandins. Possible involvement of certain immunoregulatory/inflammatory cytokines (e.g. IL-1, IL-2) has been suggested. The most probable intrinsic moiety of the adamantylamide dipeptide molecule responsible for triggering the e dema formation is obvioUSly D-isoglutamine.