GAMMA-AMINOBUTYRIC ACIDA RECEPTOR SUBUNITS IN THE MEDIATION OF SELECTIVE DRUG-ACTION

Pharmacologic and biochemical data indicate a variety of gamma-aminobu tyric acid(A) receptor subtypes. The identification of gamma-aminobuty ric acid(A) receptor subunits and their isoforms has yielded a more re fined characterization of the pharmacologic selectivity of these sites . Such structural diversity may explain the different responses noted with drugs acting through gamma-aminobutyric acid(A) receptors and mak es possible the design of new agents capable of selectively manipulati ng this neurotransmitter system.