THE HUMAN LEUCINE ZIPPER-CONTAINING GUANINE-NUCLEOTIDE EXCHANGE PROTEIN ELONGATION FACTOR-1-DELTA

Copy-DNA clones containing the complete coding region of the human elo ngation factor-1delta (EF-1delta) mRNA have been isolated and characte rized. We present the deduced amino acid sequence and observe in it a leucine zipper motif seen recently in EF-1delta from Artemia and Xenop us laevis. The human EF-1delta sequence shows a strong conservation in its C-terminal domain. The homology between the N-terminal domains of EF-1delta proteins is low and almost exclusively limited to the leuci ne zipper motif.