THE ROLE OF THE BETA-SUBUNIT OF INITIATION FACTOR-EIF-2 IN INITIATIONCOMPLEX-FORMATION

Authors
FLYNN A OLDFIELD S PROUD CG
Citation
A. Flynn et al., THE ROLE OF THE BETA-SUBUNIT OF INITIATION FACTOR-EIF-2 IN INITIATIONCOMPLEX-FORMATION, Biochimica et biophysica acta, 1174(1), 1993, pp. 117-121
Citations number
32
Categorie Soggetti
Biophysics,Biology
Journal title
Biochimica et biophysica acta → ACNP
ISSN journal
00063002
Volume
1174
Issue
1
Year of publication
1993
Pages
117 - 121
Database
ISI
SICI code
0006-3002(1993)1174:1<117:TROTBO>2.0.ZU;2-F
Abstract
The functional properties of preparations of protein synthesis initiat ion factor eIF-2 which lack the beta-subunit (as confirmed immunologic ally) were compared with those of the heterotrimeric factor. The forme r can bind guanine nucleotides but not initiator tRNA, and also exhibi ts a substantially reduced rate of initiation factor eIF-2B-mediated G DP/GTP-exchange.