IMPAIRMENT OF ENDOTHELIUM-DEPENDENT RELAXATION OF SUPERIOR MESENTERIC-ARTERY IN GENETICALLY DIABETIC WBN KOB RATS

Authors
MIYATA N YAMAURA H TSUCHIDA K OKUYAMA S OTOMO S KAMATA K KASUYA Y
Citation
N. Miyata et al., IMPAIRMENT OF ENDOTHELIUM-DEPENDENT RELAXATION OF SUPERIOR MESENTERIC-ARTERY IN GENETICALLY DIABETIC WBN KOB RATS, Canadian journal of physiology and pharmacology, 71(3-4), 1993, pp. 297-300
Citations number
19
Categorie Soggetti
Pharmacology & Pharmacy",Physiology
Journal title
Canadian journal of physiology and pharmacology → ACNP
ISSN journal
00084212
Volume
71
Issue
3-4
Year of publication
1993
Pages
297 - 300
Database
ISI
SICI code
0008-4212(1993)71:3-4<297:IOEROS>2.0.ZU;2-S
Abstract
The endothelium-dependent relaxation of superior mesenteric arteries o f Wistar and genetically diabetic WBN/Kob rats was compared. Endotheli um-dependent relaxation induced by acetylcholine (ACh) and A23187 was depressed in WBN/Kob rats. Relaxation induced by sodium nitroprusside, an endothelium-independent agent, in strips from WBN/Kob rats was sim ilar to that in strips from Wistar rats. Indomethacin (5 x 10(-6) M) e nhanced the relaxation responses to ACh in strips from both WBN/Kob an d Wistar rats; however, endothelium-dependent relaxation induced by AC h remained attenuated in WBN/Kob rats. These results show that endothe lium-dependent relaxation is impaired not only in thoracic aorta but a lso in superior mesenteric arteries in genetically diabetic rats.