KI-1-POSITIVE LARGE-CELL ANAPLASTIC LYMPHOMA DIAGNOSED BY URINARY CYTOLOGY - A CASE-REPORT

Cytomorphologic and immunocytochemical findings in urinary cytology in a case of Ki-1-positive large cell anaplastic lymphoma in the left ce rvical region in a 42-year-old man are reported. Smears stained with P apanicolaou or Wright-Giemsa stain showed a cytomorphologic spectrum t hat varied from immunoblastlike cells to large neoplastic cells with p leomorphic nuclei and vacuolated cytoplasm. Neoplastic cells with mult ilobulated, bizarre nuclei and mitosis were also observed. Immunocytoc hemistry on urinary sediments showed that the tumor cells were of a '' null'' phenotype and strongly expressed the Ki-1 antigen and ''activat ion'' markers of HLA-DR, Tac (CD25) and OKT9 (CD71). Histology and imm unohistochemistry confirmed these findings.