The cytologic features of malignant ameloblastoma, a rare tumor of the
jaw, are described. Fine needle aspiration smears showed high cellula
rity, with small basaloid and polygonal epithelial cells with mild to
moderate pleomorphism lying singly or in clusters, In Giemsa-stained s
mears, pinkish stroma with stellate cells or irregularly shaped nuclei
and isolated spindle cells were seen in the background. Histopatholog
y of the tumor showed sheets of cells with features of malignancylike
atypical mitosis and vascular invasion. The tumor cells stained positi
ve for keratin on immunohistochemistry. A review of cytology smears re
vealed that the features were sufficiently characteristic of an amelob
lastoma, but it was difficult to label the lesion malignant on fine ne
edle aspiration cytology.