EPSP SYNTHASE INHIBITOR DESIGN .2. THE IMPORTANCE OF THE 3-PHOSPHATE GROUP FOR LIGAND-BINDING AT THE SHIKIMATE-3-PHOSPHATE SITE AND THE IDENTIFICATION OF 3-MALONATE ETHERS AS NOVEL 3-PHOSPHATE MIMICS

Authors
MILLER MJ ANDERSON KS BRACCOLINO DS CLEARY DG GRUYS KJ HAN CY LIN KC PANSEGRAU PD REAM JE SAMMONS RD SIKORSKI JA
Citation
Mj. Miller et al., EPSP SYNTHASE INHIBITOR DESIGN .2. THE IMPORTANCE OF THE 3-PHOSPHATE GROUP FOR LIGAND-BINDING AT THE SHIKIMATE-3-PHOSPHATE SITE AND THE IDENTIFICATION OF 3-MALONATE ETHERS AS NOVEL 3-PHOSPHATE MIMICS, Bioorganic & medicinal chemistry letters, 3(7), 1993, pp. 1435-1440
Citations number
25
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
3
Issue
7
Year of publication
1993
Pages
1435 - 1440
Database
ISI
SICI code
0960-894X(1993)3:7<1435:ESID.T>2.0.ZU;2-J
Abstract
Studies using alternate substrates, inhibitor product mimics and new d erivatives of 4,5-dideoxy-shikimate-3-phosphate (ddS3P) are reported w hich indicate that the 3-phosphate group contributes significantly to substrate and inhibitor recognition at the shikimate 3-phosphate (S3P) site and that 3-malonate ethers will function as suitable 3-phosphate replacements for substrate and inhibitor binding to the S3P site of t his enzyme.