INFLUENCE OF PREOPERATIVE RADIOTHERAPY ON DNA-PLOIDY IN SQUAMOUS-CELLCARCINOMAS OF THE ESOPHAGUS

Citation
R. Porschen et al., INFLUENCE OF PREOPERATIVE RADIOTHERAPY ON DNA-PLOIDY IN SQUAMOUS-CELLCARCINOMAS OF THE ESOPHAGUS, Gut, 34(8), 1993, pp. 1086-1090
Citations number
32
Categorie Soggetti
Gastroenterology & Hepatology
Journal title
GutACNP
ISSN journal
00175749
Volume
34
Issue
8
Year of publication
1993
Pages
1086 - 1090
Database
ISI
SICI code
0017-5749(1993)34:8<1086:IOPROD>2.0.ZU;2-U
Abstract
The influence of preoperative radiotherapy on the prevalence of DNA an euploidy and the prognostic significance of tumour DNA ploidy was eval uated in 126 patients with squamous cell carcinoma of the oesophagus. Preoperative radiotherapy with 30 Gy was performed in 52 patients. DNA ploidy was analysed by flow cytometry on nuclei isolated from paraffi n embedded tumour tissue. DNA aneuploidy was identified in 75 tumours (61%) and found to correlate significantly with tumour stage. The perc entage of aneuploid carcinomas was significantly reduced by preoperati ve radiotherapy (surgery only group, 71%; radiotherapy group, 47%, p=0 .01). Although the median survival time was slightly better in the dip loid than in the aneuploid group (11.3 and 8.0 months respectively), t his difference was not statistically significant. A curative tumour re section was the most important prognostic factor. Preoperative radioth erapy did not prolong survival in oesophageal cancer.