OROPHARYNGEAL DECONTAMINATION - BIOADHESIVE POWDER MIXTURE FORMULATION .1. CHOICE OF THE BIOADHESIVE MATERIAL

Authors
CHARRUEAU C ARNAUD P DURIEUX J ALLAIN P CHAUMEIL JC
Citation
C. Charrueau et al., OROPHARYNGEAL DECONTAMINATION - BIOADHESIVE POWDER MIXTURE FORMULATION .1. CHOICE OF THE BIOADHESIVE MATERIAL, Journal of controlled release, 26(1), 1993, pp. 49-57
Citations number
22
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Journal of controlled release → ACNP
ISSN journal
01683659
Volume
26
Issue
1
Year of publication
1993
Pages
49 - 57
Database
ISI
SICI code
0168-3659(1993)26:1<49:OD-BPM>2.0.ZU;2-7
Abstract
The aim of this study was to improve the administration form of the or opharyngeal decontaminating mixture manufactured at the ''Pharmacie Ce ntrale des Hopitaux de Paris''. Five tests (slide, Nogami apparatus, t ablet, coagulation automator and in vitro bioadhesion) were carried ou t with 19 products with the aim of selecting the product best fitted t o the administration form: a powder dispersed in the buccal cavity, bi oadhesive in situ, and forming a gel with saliva. Natrosol 250 HHX Pha rm(R) (H.E.C.) was chosen for its wetting and bioadhesive properties a s well as its gelation rate.