This article is a reflection on the development and orientation of reg
ional science in Europe in the past decade. It particularly views prog
ress in regional science as a result of new combinations that follow f
rom the pace of advance in theory, research tools and techniques, chan
ges in the map of the European economy, and the rise of new spatial po
licy questions. Of particular importance are two megatrends that have
influenced the orientation of regional science in Europe, namely the u
nification of Europe and the shift to a network economy.