IS CYCLIC NEUTROPENIA A DISEASE OR A SYND ROME

Peripheral blood and bone marrow morphology, blood and bone marrow lym phocyte subpopulation composition were studied in two children with cy clic neutropenia, using flow cytofluorometry, monoclonal antibodies, c olony-forming capacity of granulocytic macrophagal precursors in semi- fluid agar. The studies were conducted in varying periods of the neutr openic cycle. Differences were revealed in immunohematologic parameter s and clinical course of neutropenia in the two patients. The analysis of the literature data and the authors' own observations of the patie nts with cyclic neutropenia permitted a suggestion on high heterogenei ty of pathogenetic mechanisms of this disease.