Ma. Pfeifer et al., A HIGHLY SUCCESSFUL AND NOVEL MODEL FOR TREATMENT OF CHRONIC PAINFUL DIABETIC PERIPHERAL NEUROPATHY, Diabetes care, 16(8), 1993, pp. 1103-1115
Citations number
82
Categorie Soggetti
Endocrynology & Metabolism","Medicine, General & Internal
OBJECTIVE - To investigate why, in spite of a vast variety of treatmen
t agents, the alleviation of pain in patients with diabetic neuropathy
is difficult. Previous studies have not used a treatment algorithm ba
sed on anatomic site and neuropathophysiological source of the neuropa
thic pain. RESEARCH DESIGN AND METHODS - A model that categorizes the
types of pain into three groups (superficial, deep, and muscular) was
applied in 75 diabetic patients with chronic (> 12 mo) painful distal
symmetrical polyneuropathy in a controlled case series. Twenty-two pat
ients were untreated and 53 patients were treated with imipramine +/-
mexiletine for deep pain, capsaicin for superficial pain, and stretchi
ng exercises and metaxalone +/- piroxican for muscular pain. Each type
of pain was scored separately on a scale of 0 (none) to 19 (worst), a
nd the total of all three types was used as an index of overall pain.
Ability to sleep through the night was scored by a scale of 1 (never)
to 5 (always). RESULTS - No significant differences were observed in i
nitial pain scores, sleep scores, demographics, biochemistries, or phy
sical findings between the two groups. After 3 mo a significant improv
ement in scores was noted in the treated but not the untreated patient
s. In addition, a significant difference was found in the change of sc
ores between die treated and untreated patients: total pain (- 18 +/-
2 vs. 0 +/- 2), deep pain (- 7 +/- 1 vs. 0 +/- 1), superficial pain (-
5 +/- 1 vs. 0 +/- 1), muscular pain (-6 +/- 1 vs. 0 +/- 1), and sleep
(1.2 +/- 0.2 vs. 0.2 +/-0.2), all P < 0.0001. In treated patients 21%
became pain-free (total pain < 2), 66% had improvement (decrease in to
tal pain >5, but not total elimination of painful symptoms), and 13% w
ere considered treatment failures (a decrease in total pain of less-th
an-or-equal-to 5). This compares with 0 (P < 0.02), 10 (P < 0.0001), a
nd 90% (P < 0.0001), respectively, in the untreated patients. CONCLUSI
ONS- This study presents a new rationale and hypothesis for the succes
sful treatment of chronic painful diabetic peripheral neuropathy. It u
niquely bases the treatment algorithm on the types and sources of the
pain.