DETERMINATION OF KINETICS OF HYDROLYSIS BY HIGH-PRESSURE LIQUID-CHROMATOGRAPHY - APPLICATION TO HYDROLYSIS OF THE ETHYLENE-GLYCOL BUTYL ETHER ESTER OF TRICLOPYR

Using a high-pressure liquid chromatographic (HPLC) method capable of determining 3,5,6-trichloro-2-pyridinol (P), triclopyr (T), and the et hylene glycol butyl ether ester of T (G) in aqueous media without extr action or cleanup, the pseudo-first-order rate constants for the hydro lysis of G were established at 35-degrees-C in aqueous buffered soluti ons of pH 4.5-8.5. The reaction was base-catalyzed and the rate propor tional to the pH ranging from 3.63 x 10(-4) to 0.1596 h-1. The major c onversion product was T at pH 4.5-8.5, and P was an additional minor p roduct at pH 4.5. Both products were stable in aqueous media. The hydr olysis of G was determined according to the same approach in two river waters of pH 6.6 and 7.6. Their kinetics were in agreement with those in aqueous buffers of the same pH with low ionic strength to reduce o r eliminate buffer catalysis.