CARDIOVASCULAR ACTIONS OF ANGIOTENSIN(1-7)

Angiotensin(1-7) had a compound effect on blood pressure of pithed Spr ague-Dawley rats. The initial phase of the response consisted of an in crease in MAP of short duration and independent of injected dose, foll owed by a decline of arterial pressure to values below baseline. Both the magnitude (range: -4 +/- 1 to -13 +/- 1 mmHg) and the duration (ra nge: 83 +/- 13 to 255 +/- 17 s) of the depressor response correlated w ith the dose of peptide. Indomethacin (5 mg/kg) eliminated the depress or component. Only [Sar1,Thr8]Ang II inhibited the effect of Ang(1-7) completely. We conclude that angiotensin(1-7) possesses myotonic actio ns that are in part related to release of vasodilator prostaglandins t hrough an angiotensin receptor other than AT1 or AT2.