[H-3] SAXITOXINOL METABOLISM AND ELIMINATION IN THE RAT

Authors
HINES HB NASEEM SM WANNEMACHER RW
Citation
Hb. Hines et al., [H-3] SAXITOXINOL METABOLISM AND ELIMINATION IN THE RAT, Toxicon, 31(7), 1993, pp. 905-908
Citations number
7
Categorie Soggetti
Toxicology,"Pharmacology & Pharmacy
Journal title
Toxicon → ACNP
ISSN journal
00410101
Volume
31
Issue
7
Year of publication
1993
Pages
905 - 908
Database
ISI
SICI code
0041-0101(1993)31:7<905:[SMAEI>2.0.ZU;2-Y
Abstract
Tritiated saxitoxinol was used to obtain preliminary information on sa xitoxin metabolism in the rat. Sublethal doses of tritiated saxitoxino l (18.9-muCi/kg; 3.8 mug/kg) were injected i.v. into each of six rats. Urine and fecal samples were collected up to 144 hr post-injection. W ithin 4 hr, 60% of injected radioactivity was excreted in urine. No ra dioactivity was found in feces. High performance liquid chromatography analyses of urine showed that saxitoxinol was not metabolized by the rats.