REVERSED-PHASE LIQUID-CHROMATOGRAPHY OF SOME BENZIMIDAZOLE DERIVATIVES

The retention behaviour of a series of benzimidazole derivatives has b een studied as a function of the water content of aqueous methanol and aqueous acetonitrile eluents. The relationship between the retention constant (log k) and the pH of the aqueous phase was linear, with slop e values depending on the composition of the aqueous phase, the molecu lar structure of the compound, and the type of C-18 bonded stationary phase. The type of organic modifier significantly affected the shape o f the relationship between log k and the volume fraction of organic mo difier in the mobile phase.