Endothelin levels were measured by means of [I-125]endothelin-1,2,3 ra
dioimmunoassay in the follicular fluids of 22 mature ovarian follicles
of 11 patients, obtained during ovum pickup. In all but 1 of the foll
icles, endothelin levels were detectable and ranged between 0.2 and 3.
6 pg/ml (mean 1.47 +/- 0.99). In this preliminary study, no correlatio
n was found between follicular endothelin levels and oocyte fertilizat
ion or the hormonal ovarian response during the follicular phase.