THE ANTIINFLAMMATORY EFFECTS OF KETOPROFEN IN ANIMAL-EXPERIMENTS

The authors investigated the anti-inflammatory actions of ketoprofen u sing a battery of tests: in the rat paw oedema test induced by five di fferent inciters, in the capillary permeability test, and in measuring the interleukin-8 (IL-8) production and superoxide dismutase (SOD) ac tivity. The findings in these studies show that ketoprofen inhibits ra t paw oedema, suppresses capillary permeability, reduces IL-8 producti on and increases SOD activity in the acetic-acid-induced inflammatory state. These results would seem to provide a clear rationale for explo ring the usefulness of ketoprofen in the treatment of acute and chroni c inflammatory diseases.