EFFECT OF 2 INHIBITORS ON SUCCINIC-DEHYDROGENASE ACTIVITY IN CEREBRALHEMISPHERES OF MALE GARDEN LIZARDS OF 3 DIFFERENT AGE-GROUPS

Age changes in the specific activity of cerebral succinic dehydrogenas e (SDH) and the effect of two inhibitors (malonate and p-chlorophenoxy acetic acid) on enzyme activity were traced in a short-lived species of reptile, Calotes versicolor, the garden lizard. The enzyme activity reached a peak level in middle-aged lizards followed by a decline in old counterparts. The enzyme inhibitions by both the inhibitors were s ignificantly higher in old than in middle-aged and young lizards sugge sting a change in specificity of SDH molecules during ageing.