Rl. Galloway et al., FACTORS AFFECTING PERCEIVED TUMOR VOLUMES IN MAGNETIC-RESONANCE-IMAGING, Annals of biomedical engineering, 21(4), 1993, pp. 367-375
Irregularly structured brain tumors, such as glioblastomas, challenge
attempts to visualize and quantify their three-dimensional structure.
Magnetic resonance imaging (MRI) represents one tool for attempting to
noninvasively track tumor size. MR images demonstrate widely varying
perceived tumor margins. In addition, adjunct therapies, such as the a
dministration of steroids, greatly affect the volumes perceived in ima
ges formed by certain pulse sequences. In this study tumors were grown
in 15 dogs and the tumor size tracked for a period of time. The dogs
were placed on dexamethasone for a week and another series of scans wa
s obtained. No other therapies were provided. The data for visualized
tumor size are provided for T1, T2, and proton density. Weighted image
s are provided and the relationships between the scans are discussed.