SOME BIOCHEMICAL ASPECTS OF THE PROTECTIVE EFFECT OF STRONTIUM CHLORIDE ON GAMMA-IRRADIATED RATS

The effect of treatment with SrCl2 (10 Mg 100 g-1) on rats 15 min prio r to the whole body gamma-irradiation (7.5 Gy) was studied. The hazard ous effects of irradiation were greatly corrected in the treated group . The hyperglycemic effect and liver glycogen accumulation in the untr eated group decreased to normal level. The enzymatic activities of ser um alkaline phosphatase, alanine and aspartate aminotransferases, and lactate dehydrogenase were greatly affected, showing insignificant cha nges in the treated group of animals. Life span calculated on 50% surv ival was also significantly elongated by 36.3%. These results show the potentiality of SrCl2 as a radioprotective agent. A proposed mechanis m is discussed.