A biosensor is defined as a device that incorporates a biological comp
onent which is either intimately connected to or integrated within a t
ransducer. Biocatalysts, such as specialized tissues from higher anima
ls and plants, have been incorporated into various electrochemical tra
nsducers to construct biosensors for the detection of important analyt
es. The receptor-based biosensors utilize isolated receptors or whole
intact receptor organisms as molecular recognition elements for the de
tection of various important analytes including drugs, hormones, toxic
ants, neurotransmitters and amino acids. The immobilization of isolate
d receptors on transducers such as ISFETs, 'electric capacitors and op
tical fibers for biosensing has been given significant consideration r
ecently. Intact chemoreceptor-based biosensors, in particular, offer s
everal advantages including extremely short response time, a high degr
ee of sensitivity, a wide range of linear response and inherent select
ivity. This review highlights some of the recent advances in plant and
animal tissue-based biosensors, with emphasis on historical developme
nts.