The lactate profile in serum was monitored continuously in volunteers
under physical exercise on a test bicycle. The assay was operated ex v
ivo by means of continuous sampling through a coaxial catheter. After
dialysis on-line, lactate was converted by means of lactate oxidase im
mobilized to porous glass, and the depletion of oxygen was registered
by means of a Clark electrode. Good agreement between the continuous m
onitoring and off-line analyses was found.