INTRACEREBRAL AND SUBCUTANEOUS XENOGRAFTS OF HUMAN SCLC IN THE NUDE RAT - COMPARISON OF MONOCLONAL-ANTIBODY LOCALIZATION AND TUMOR-INFILTRATING LYMPHOCYTES

In the WAG/Rij nude rat, subcutaneous (s.c.) and intracerebral (i.c.) xenografts of the human SCLC cell line GLC-28 were evaluated for their growth behavior, in vivo monoclonal antibody binding and presence of tumor infiltrating lymphocytes. For the i.c. xenografts, two models of cerebral tumor growth were studied, one in the cerebral cortex and on e in the lateral ventricle of the brain. In the s.c. and both i.c. xen ografts models, in vivo localization of anti-carcinoma moab MOC-31 occ urred within 4 hours after i.p. injection, with a maximal binding at 2 4 h after injection. A pronounced tumor infiltration of predominantly NK cells was observed for s.c. and intraventricular xenografts, but no t for the GLC-28 tumors xenografted in the cerebral cortex. The presen ted nude rat/GLC-28 xenograft models may be used for the in vivo testi ng of experimental imaging techniques or alternative treatment strateg ies relevant to brain metastases of human SCLC.