Between January 1976 and June 1991, 161 women underwent restorative pr
octocolectomy. Seventeen (10.6 per cent) developed pouch-vaginal fistu
la. There was no difference in the incidence of inflammatory (15 of 14
1; 10.6 per cent) and non-inflammatory (two of 20; 10 per cent) diseas
e, the severity of colitis or the number of stages in the operation. I
n 15 patients the fistula involved the ileoanal anastomosis; in two it
had possibly occurred at the dentate line. There was no significant d
ifference in the proportion of hand-sewn (ten of 120; 8.3 per cent) an
d stapled (seven of 41; 17 per cent) ileoanal anastomosis. Of the 17 w
omen, six had pelvic sepsis in the immediate postoperative period and
five had an anastomotic complication. There was no case of Crohn's dis
ease. Three patients developed a pouch-vaginal.fistula before closure
of the ileostomy. The remaining 14 fistulas occurred a median of 7 (ra
nge 1-144) months after closure. Five further patients were referred f
rom elsewhere to give a total of 22 for analysis of treatment and outc
ome. The fistula developed before ileostomy closure in five patients (
group 1) and after closure in 17 (group 2). Following treatment, six f
istulas had healed with five patients still undergoing treatment. In g
roup 1, three of the five fistulas healed, whereas in group 2 only thr
ee of the 17 healed. Eight patients required excision of the pouch. Th
e prognosis appears to be worse when pouch-vaginal fistula occurs afte
r ileostomy closure. The optimal management is not yet established.