A theoretical boundary friction model is proposed for predicting the f
rictional behavior of articular cartilage, including its time-dependen
t, velocity-dependent, and load-dependent responses. This theoretical
model uses the framework of the biphasic theory for articular cartilag
e, and provides a mathematical formulation for the principle that inte
rstitial fluid pressurization contributes significantly to reduction o
f the effective friction coefficient. Several examples of the applicat
ion of this theory are provided, which demonstrate that a variety of e
xperimentally observed cartilage frictional behaviors can now be theor
etically predicted.