We used the records of a statewide pediatric mortality surveillance sy
stem to determine mortality rates and causes of death in children with
epilepsy. Of the 1,095 children aged 1-14 years who died in the state
of Victoria during the study period 1985-1989, 93 had a history of ep
ilepsy. Six children (6%) had primary epilepsy, and 87 (94%) had secon
dary epilepsy. Death was (a) directly attributable to epilepsy in 20 (
22%), including 11 with sudden unexplained death, (b) not directly att
ributable to epilepsy in 59 (63%), and (c) of undetermined cause in 14
(15%). No classifiable death occurred as a direct result of status ep
ilepticus. The average annual mortality rates for children with epilep
sy were (a) death from all causes, 30.6 in 10,000 [95% confidence inte
rval (CI) 19.7, 47.5], and (b) death attributable to epilepsy, 6.6 in
10,000 (95% CI 3.7, 11.8). Relative to the all-cause mortality rate in
children without epilepsy, the all-cause mortality rate ratios were (
a) all children with epilepsy, 13.2 (95% CI 8.5, 20.7); (b) primary ep
ilepsy, 1.1 (95% CI 0.5, 2.6); and (c) secondary epilepsy, 49.7 (95% C
I 31.7, 77.9). The mortality rate ratios for secondary epilepsy relati
ve to primary epilepsy were (a) death from all causes, 43.5 (95% CI 19
.0, 99.5); and (b) death attributable to epilepsy, 9.0 (95% CI 3.3, 24
.8). Epilepsy appeared on the death certificate of only 11 of 20 (55%)
children whose deaths were attributable to epilepsy. We conclude that
(a) there was an increased risk of death during childhood in children
with epilepsy; (b) the risk of death was greatest for children with s
econdary epilepsy; (c) potentially preventable, epilepsy-related death
s occurred in children with primary epilepsy; (d) sudden unexplained d
eath accounted for at least 12% of deaths; and (e) death certification
was deficient with respect to recording of epilepsy.