SELENIUM-CATALYZED AND PALLADIUM-CATALYZED OXIDATIVE CLEAVAGE OF ENE-LACTAMS WITH HYDROGEN-PEROXIDE - CONVENIENT METHODS FOR SYNTHESIS OF MACROCYCLIC KETOIMIDES AND N-FUSED AZABICYCLIC COMPOUNDS

Authors
NAOTA T SASAO S TANAKA K YAMAMOTO H MURAHASHI SI
Citation
T. Naota et al., SELENIUM-CATALYZED AND PALLADIUM-CATALYZED OXIDATIVE CLEAVAGE OF ENE-LACTAMS WITH HYDROGEN-PEROXIDE - CONVENIENT METHODS FOR SYNTHESIS OF MACROCYCLIC KETOIMIDES AND N-FUSED AZABICYCLIC COMPOUNDS, Tetrahedron letters, 34(30), 1993, pp. 4843-4846
Citations number
20
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
34
Issue
30
Year of publication
1993
Pages
4843 - 4846
Database
ISI
SICI code
0040-4039(1993)34:30<4843:SAPOCO>2.0.ZU;2-Q
Abstract
Oxidative cleavage of ene-lactams can be performed efficiently by eith er SeO2 or Pd(OAc)2-catalyzed oxidation with H2O2 to give the correspo nding ketoimides. The reaction provides convenient methods for the pre paration of macrocyclic ketoimides and the construction of N-fused aza bicyclic ring systems such as indolizidine and cephalotaxine skeletons .