INCREASED RISK OF MENINGITIS AND BACTEREMIA DUE TO LISTERIA-MONOCYTOGENES IN PATIENTS WITH HUMAN-IMMUNODEFICIENCY-VIRUS INFECTION

The incidence, demographics, and clinical outcome of infections due to Listeria monocytogenes in individuals infected with the human immunod eficiency virus (HIV) were evaluated by prospective population-based s urveillance. During a 2-year study period, 37 cases of invasive lister iosis occurred in metropolitan Atlanta (annual incidence, 0.8 case per 100,000 population). Seven of these cases occurred in known HIV-infec ted individuals (19% of all cases); five had an AIDS-defining illness, and the other two had CD4 lymphocyte cell counts of <200/muL. The est imated incidence of listeriosis among HIV-infected patients in metropo litan Atlanta was 52 cases per 100,000 patients per year, and among pa tients with AIDS it was 115 cases per 100,000 patients per year, rates 65-145 times higher than those among the general population. HIV-asso ciated cases occurred in adults who were 29-62 years of age and in pos tnatal infants who were 2 and 6 months of age. Mortality among the HIV -infected group was 29%. L. monocytogenes serotypes 1/2a, 1/2b, and 4b were isolated from the HIV-infected patients. L. monocytogenes is an important opportunistic pathogen in HIV-infected patients.