E. Kicic et al., RESTRICTION-FRAGMENT-LENGTH-POLYMORPHISMS OF THE HUMAN ALDOSE REDUCTASE GENE - A PRELIMINARY-REPORT, Diabetes research and clinical practice, 20(2), 1993, pp. 165-168
Abnormal metabolism through the polyol pathway during episodes of hype
rglycaemia is implicated in the development of the chronic complicatio
ns of diabetes. Since aldose reductase is the first and rate-limiting
enzyme of the polyol pathway, it is predicted that restriction fragmen
t length polymorphisms at the aldose reductase gene locus may influenc
e catalytic activity and determine individual susceptibility to the di
abetic complications. This paper reports the existence of EcoRI and Ta
qI restriction fragment length polymorphisms at the human aldose reduc
tase locus.