RESTRICTION-FRAGMENT-LENGTH-POLYMORPHISMS OF THE HUMAN ALDOSE REDUCTASE GENE - A PRELIMINARY-REPORT

Abnormal metabolism through the polyol pathway during episodes of hype rglycaemia is implicated in the development of the chronic complicatio ns of diabetes. Since aldose reductase is the first and rate-limiting enzyme of the polyol pathway, it is predicted that restriction fragmen t length polymorphisms at the aldose reductase gene locus may influenc e catalytic activity and determine individual susceptibility to the di abetic complications. This paper reports the existence of EcoRI and Ta qI restriction fragment length polymorphisms at the human aldose reduc tase locus.